Struggling with headache relief and migraine pain? Stay hydrated!
In Short: Understanding dehydration and headaches can offer significant insights into alleviating discomfort and improving overall wellness. Hydration is essential for effective headache relief and reducing the severity of tension headaches and chronic migraines. By recognizing the headache causes linked to dehydration, you empower yourself with knowledge to tackle migraine triggers and nausea with headache more effectively. Pulse Align Clinics propose innovative hydration strategies to enhance your lifestyle and support natural headache remedies. Reclaim your health and wellness at Pulse Align Clinics. Book your appointment today!
Are you struggling with lower back pain and poor posture?
Understanding dehydration and headaches: insights from a Pulse Align perspective on maintaining hydration highlights the critical connection between proper fluid intake and effective headache relief. Studies show that approximately 75% of adults experience chronic headaches, often exacerbated by dehydration and leading to discomfort associated with tension headaches, migraine pain, and even nausea with headache. By focusing on hydration as a foundational element of wellness, Pulse Align offers innovative solutions that address not just headache causes, but also contributes to posture correction and core strengthening. Discover how maintaining hydration can effectively reduce the impact of migraine triggers, improve overall wellness, and foster a supportive community for those seeking natural headache remedies.
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Understanding Dehydration and Headaches: Insights from a Pulse Align Perspective
In today’s world, where many individuals are grappling with discomfort related to hydration, addressing such concerns is crucial for overall wellness. Maintaining proper hydration levels is essential for posture improvement and neuromuscular recalibration, leading to better balance and well-being. This article will explore how Pulse Align’s gentle approach to restoring natural balance can support your wellness journey.
Embracing Natural Balance
Every day, your body benefits from effective hydration, which plays a pivotal role in its overall function. By promoting muscle tone symmetry and fostering gentle stimulation, Pulse Align focuses on restoring natural balance, helping clients feel revitalized. This method encourages the body’s ability to engage in its healing processes naturally, aligning with the overarching goal of enhancing well-being.
The Holistic Advantages of Pulse Align
As part of a holistic approach to wellness, Pulse Align emphasizes the body’s inherent ability to heal itself. Clients often share their positive experiences, with many mentioning how they have been able to improve posture naturally and reduce neck discomfort through the integration of simple hydration practices into their daily routines. These testimonials highlight the transformative potential of Pulse Align’s supportive community and innovative techniques.
Join the Pulse Align Family
If you’re interested in nurturing your wellness journey through improved hydration and supportive techniques, consider visiting Pulse Align. With clinic locations in Montreal, La Prairie, Terrebonne, Chicoutimi, Charlesbourg, Saint-Jérôme, Châteauguay, Sainte-Marie, Les Escoumins, Granby, and Panama City, you can easily find a clinic near you. Book a consultation today and embrace a healthier lifestyle, understanding that Pulse Align beautifully complements existing healthcare services while empowering your body to find its natural balance.
Understanding Dehydration and Headaches
- Impact of Dehydration: Increases headache severity and frequency.
- Hydration Recommendations: Aim for at least 8 glasses of water daily.
- Hydrating Foods: Include fruits and vegetables such as watermelon and cucumber.
- Caffeine Effects: Limit intake as it can lead to dehydration.
- Signs of Dehydration: Thirst, dry mouth, and dark urine indicate the need for hydration.
- Reminders to Hydrate: Set alerts throughout the day to keep drinking water.
- Physical Activity: Stay active to help maintain hydration levels.
- Natural Remedies: Use essential oils for headache relief in conjunction with hydration.
Chronic headaches, including tension and migraine pain, significantly affect daily life for many individuals. One often-overlooked culprit is dehydration. Understanding the relationship between hydration and headache relief is paramount for those seeking effective natural headache remedies. This article will delve into how maintaining optimal hydration can alleviate headache symptoms, improve neuromuscular health, and restore natural balance.
Hydration’s Impact on Headache Causes
Research shows that dehydration is a common trigger for various types of headaches, including chronic migraines and tension headaches. Dehydration can exacerbate symptoms such as nausea with headache and pain behind the eyes. Understanding these headache causes can empower individuals to take proactive measures in their wellness journey. By staying adequately hydrated, individuals may experience reduced headache frequency and intensity.
The Role of Neuromuscular Health and Posture Improvement
At Pulse Align, we emphasize the importance of neuromuscular health in preventing headaches. Proper hydration contributes to posture correction by ensuring that muscles maintain optimal function. Adequate hydration supports nervous system recalibration, thereby enhancing overall body symmetry. By focusing on core strengthening exercises and trunk exercises, individuals can minimize tension that contributes to headaches.
Hydrating Foods and Dietary Considerations
Aside from drinking water, consuming hydrating foods can further support headache management. Incorporating fruits and vegetables, such as watermelon and cucumber, into a migraine diet can help maintain hydration levels. Additionally, it’s important to identify foods that trigger migraines and limit them to prevent discomfort. Opting for electrolyte-rich drinks post-exercise can also promote hydration and overall well-being.
Natural Headache Remedies for Effective Relief
Utilizing essential oils for headaches is a popular natural remedy that can provide additional comfort. Research indicates that oils like peppermint and lavender can help relieve headache tension. Coupling these remedies with proper hydration and awareness of migraine triggers can lead to more effective migraine relief. Furthermore, implementing headache relief pressure points may complement these natural remedies and enhance comfort.
Actionable Hydration Tips for Headache Management
Implementing hydration strategies into your daily routine can greatly impact headache relief. Here are actionable tips:
- Monitor Water Intake: Aim for at least eight glasses of water daily, adjusting for activity levels and climate.
- Limit Caffeine: High caffeine intake may worsen dehydration and should be monitored, particularly for those with hormonal headaches.
- Set Hydration Reminders: Establish reminders to drink water throughout the day, ensuring consistent fluid intake.
Call to Action: Enhance Your Wellness Journey
Understanding the critical connection between dehydration and headaches is essential for reclaiming your health. If you are struggling with tension headaches or chronic migraines, don’t wait—take charge of your health today. Book a consultation with Pulse Align to explore personalized exercise plans focused on hydration, core strengthening, and holistic approaches to wellness. Our clinics in Montreal, La Prairie, and Panama City are here to support your journey towards a balanced, headache-free life.
Understanding Dehydration and Headaches
| Aspect | Insights from Pulse Align |
|---|---|
| Connection | Dehydration significantly increases headache severity and frequency. |
| Hydration Goals | Aim for at least 8 glasses of water daily for optimal fluid intake. |
| Hydrating Foods | Fruits and vegetables, such as watermelon and cucumbers, support hydration. |
| Caffeine Effects | Limit caffeinated beverages, as they can worsen dehydration. |
| Signs of Dehydration | Thirst, dry mouth, and dark urine indicate a need for hydration. |
| Monitoring Triggers | Track hydration levels to identify personal headache triggers. |
| Exercise Considerations | Stay active while ensuring appropriate fluid intake to prevent dehydration. |
| Mindful Reminders | Set alerts to encourage regular water intake throughout the day. |
Transformative Wellness Journeys: Client Testimonials on Staying Hydrated
In La Prairie, numerous clients have voiced their appreciation for the insights provided by Pulse Align regarding the connection between dehydration and headaches. One client shared, “By focusing on hydration, I’ve been able to experience significant improvements in my overall well-being. The team at Pulse Align helped me understand how maintaining proper hydration can relieve my headache symptoms naturally.” This emphasis on hydration has empowered many to embrace a more balanced lifestyle.
Residents of Mont-Royal have also seen remarkable benefits from Pulse Align’s unique approach. One client noted, “After learning about the impacts of dehydration on my headaches, I’ve committed to drinking more water daily. The gentle support from the staff has aided my body’s natural ability to recalibrate, resulting in fewer headaches and more energy throughout the day.” This acknowledgment of how hydration can enhance wellness reflects the transformative experiences clients are having.
In Terrebonne, individuals have expressed gratitude for the focus on hydration paired with holistic practices. One satisfied client reported, “Integrating hydration techniques from Pulse Align into my routine made a real difference. It’s incredible how much impact simple changes can have. I now feel more aligned and focused, allowing me to engage fully in daily activities without the burden of constant headaches.” The supportive atmosphere at Pulse Align is contributing significantly to the wellness journeys of many in the community.
Chicoutimi residents have experienced positive shifts in their wellness through Pulse Align’s insights. A client mentioned, “Realizing the connection between hydration and headaches has been eye-opening. Since I started implementing their recommendations, I’ve felt a greater sense of clarity and balance. My headaches have noticeably decreased.” These stories highlight how local clients are deriving value from the expertise offered at Pulse Align, demonstrating the positive outcomes that stem from their holistic approach.
For those in Châteauguay, the results have been just as impactful. One client shared, “The Pulse Align team made me realize that consistent hydration is more powerful than I ever thought. Their guidance has led to a significant reduction in my headache frequency, and I now feel more equipped to handle stress and discomfort.” This acknowledgment showcases how individuals across various locations are benefiting from a shared commitment to enhancing overall wellness.
For anyone seeking similar improvements in their health journey, exploring Our Clinics may be the first step toward achieving a balanced, headache-free life. Pulse Align works collaboratively with healthcare teams to ensure comprehensive support for clients and their families. By fostering a wellness-oriented approach, they empower individuals to embrace natural recovery methods.
Struggling with headache relief and migraine pain? Staying hydrated is essential!
In short, dehydration and headaches can lead to discomfort and exacerbate migraine triggers, intensifying tension headaches and chronic migraines. Staying hydrated is critical for effective headache relief as it helps reduce the frequency and severity of headaches while supporting overall wellness. Pulse Align Clinics promote simple, innovative strategies to enhance hydration and improve your lifestyle. Reclaim your health and wellness at Pulse Align Clinics. BOOK YOUR APPOINTMENT today!
Understanding the connection between hydration and well-being is crucial. Hydration plays a vital role in the body’s everyday function. Maintaining proper fluid intake contributes to muscle tone symmetry and overall functional balance. At Pulse Align, we emphasize gentle stimulation to help the body engage its natural healing processes, supporting alignment and improving posture.
The holistic approach of Pulse Align stands out as a trusted wellness partner. Clients often share insights about their experiences, noting that addressing hydration along with posture correction can lead to a balanced life. Many clients have reported significant improvements in their posture and a reduction in discomfort as they integrate hydration techniques into their daily routines.
Through client testimonials, it is evident how the supportive atmosphere at Pulse Align contributes to their overall well-being. Personal stories highlight that the focus on gentle, non-invasive methods not only enhances their wellness but also instills a renewed sense of vitality and balance.
Our Mission
At Pulse Align, our mission is to deliver evidence-based, client-centered treatments that address the underlying causes of pain and dysfunction. By integrating advanced techniques and technologies, we strive to empower each person to take control of their health, ensuring a high standard of care, lasting relief, and an improved quality of life.
Interested in taking a proactive step toward enhancing your wellness through better hydration and supportive techniques? Visit the Pulse Align website today to learn more about our services and how they can benefit your journey. With clinic locations in Montreal, La Prairie, Terrebonne, Chicoutimi, Charlesbourg, Saint-Jérôme, Châteauguay, Sainte-Marie, Les Escoumins, Granby, and Panama City, you can easily find a Pulse Align clinic near you. Book a consultation today and embrace a healthier lifestyle!
For more information about our approach and available services, visit www.pulsealign.com and find a location near you here.
TAGMED’s Spinal Decompression Technology: Relief from Chronic Pain
TAGMED offers advanced Spinal Decompression Therapy, a non-surgical solution specifically designed to address moderate-to-severe disc issues, including herniated discs, bulging discs, and conditions associated with spinal stenosis. By gently reducing pressure on the affected discs and nerves, this specialized technique helps enhance mobility, alleviate pain, and support your body’s natural healing process. If you’ve reached a plateau with other therapies, discover how TAGMED’s evidence-based decompression approach can help you resume an active, comfortable life.
Have you tried conventional treatments and still struggle with persistent back pain due to a severe disc condition?
Mechanism of Action
TAGMED’s neurovertebral decompression applies a controlled, progressive traction force to the spine. This method effectively increases the space between vertebrae, reducing pressure on intervertebral discs and nerve roots, which promotes better fluid circulation in the targeted area. As a result, this process helps lower inflammation and relieve pain, offering a reliable, non-invasive solution for individuals grappling with chronic back pain and associated symptoms.
Specific Benefits
This non-invasive approach can effectively alleviate chronic pain and symptoms linked to conditions like herniated discs or spinal stenosis. By reducing pressure on nerve structures and optimizing fluid circulation around the discs, neurovertebral decompression speeds up recovery and enhances the quality of life for a variety of patients seeking relief from persistent discomfort. With improved spinal health, individuals may experience a reduction in pain, allowing for an increased range of motion and the ability to return to their daily activities.
Comparison with Other Treatments
When comparing TAGMED’s neurovertebral decompression technology with other commonly used treatments, such as pain medications, corticosteroid injections, or surgery, the advantages become evident. Unlike invasive interventions, neurovertebral decompression minimizes medication-related risks and offers a quicker path to recovery. This makes it a compelling choice for those seeking safer, evidence-based alternatives. Patients appreciate not only the lack of invasive procedures but also the potential for lasting relief without dependence on pharmaceuticals.
Case Studies or Testimonials
Real-world examples of patients who have benefited from TAGMED’s neurovertebral decompression demonstrate its effectiveness for chronic pain and related symptoms. Many have reported lasting pain relief and quicker resumption of daily activities. One patient stated, “Since starting therapy, my pain has significantly decreased, and I can finally engage in life again without the shadow of discomfort.” Testimonials like these highlight the tangible results and practical advantages of this therapeutic approach, giving hope to those navigating chronic pain conditions.
Unlocking Wellness: The Pulse Align Approach to Hydration and Headache Management
Understanding the connection between dehydration and headaches is essential in navigating toward better health. At Pulse Align, we emphasize that maintaining proper hydration can lead to significant improvements in posture, reduce discomfort, increase mobility, and enhance overall well-being. Our holistic approach allows the body to gently recalibrate its neuromuscular system, fostering natural healing without invasive methods.
Client experiences at Pulse Align consistently highlight the positive transformations they undergo. Many have shared that their focus on hydration and posture correction has resulted in a revitalizing sense of energy and balance in their lives. The supportive atmosphere encourages individuals to engage in their health journeys, empowering them to reclaim their wellness amidst the challenges they face.
If you’re eager to explore a path toward improved health and wellness, we encourage you to schedule your consultation now. Discover the Pulse Align difference today as we guide you through personalized strategies for enhancing hydration and supporting your body’s natural healing abilities. Together, we can pave the way for a balanced life free from discomfort and promote your journey toward a healthier you.
Do you suffer from a condition that responds little or not at all to conservative treatments?
At Pulse Align, we understand that many individuals seek effective wellness solutions. Our innovative, non-invasive approach utilizes gentle and imperceptible pulses to help restore the body’s natural balance and posture. This natural method not only promotes muscle tone symmetry but can also alleviate common discomforts associated with tension or imbalance. By focusing on well-being rather than directly addressing discomfort, Pulse Align creates a pathway for clients to explore improved posture and overall wellness.
Pulse Align does not center its practices on discomfort or specific conditions, allowing the body to recalibrate naturally. This holistic perspective often leads to remarkable improvements in posture, comfort, and overall well-being. By embracing a gentle approach, we support the body’s own healing processes without the need for invasive methods. Our clients often find that focusing on the body’s natural alignment and balance results in feelings of increased comfort and ease in daily activities.
We take pride in our personalized approach at Pulse Align. Clients regularly share their positive experiences, noting significant improvements in alignment and overall wellness after engaging with our services. Many have reported a sense of improved balance and harmony in their lives, leading to decreased discomfort and enhanced posture. It is inspiring to witness how our holistic methods create a nurturing environment that empowers clients to thrive. Families have also appreciated the welcoming atmosphere at Pulse Align, finding that our services support everyone, including young children and expectant mothers.
Ready to explore how Pulse Align can support your wellness journey? We invite you to visit our website to learn more about the services we offer and find nearby locations, including La Prairie, Mont-Royal, Terrebonne, and more. It’s important to note that our services are designed to complement, not replace, any existing healthcare guidance. Take the next step toward improved well-being; book a consultation today for yourself or your family. Experience the gentle, non-invasive, and family-friendly approach that sets Pulse Align apart. Book your appointment online at Pulse Align.
Frequently Asked Questions
Headache and Migraine
- Does dehydration cause headaches?Yes, inadequate hydration can trigger headaches and worsen migraines.
- How long does a migraine last?An untreated migraine can last from a few hours to three days.
- Are triptans effective?Triptans target serotonin receptors and often effectively stop a migraine attack.
- What about ocular migraines?Migraines with aura can cause visual disturbances (flashing lights) before pain onset.
- Does exercise help regulate migraines?Moderate, regular exercise reduces stress and improves circulation, potentially lowering migraine frequency.
- When should I see a doctor for headaches?If headaches are frequent, intense, accompanied by unusual symptoms, or disturb your daily life.
- Are preventive medications available?Yes, beta-blockers, antidepressants, anti-epileptics, or monoclonal antibodies can prevent or reduce migraine frequency.
- Does pregnancy affect migraines?Migraines may lessen during pregnancy, especially in the second and third trimester, but it varies.
- Can migraines disappear with age?In some individuals, migraines become less frequent and less intense over time.
- What are common causes of headaches?Stress, fatigue, dehydration, muscle tension, sleep disorders, or too much caffeine can trigger a headache.
Simon Bertrand is dedicated to shining a light on the hidden struggles of chronic headaches. As a Headache Awareness Advocate at Pulse Align, he combines compassionate storytelling with cutting-edge research to bring clarity, comfort, and hope to those affected. Simon’s mission is to empower readers with knowledge, break through stigma, and foster a supportive community where every voice is heard. When he’s not crafting insightful articles, Simon can be found exploring the latest wellness trends, sharing practical coping strategies, or simply lending a listening ear to those in need. His heartfelt approach and unwavering commitment to awareness make him a trusted ally for anyone navigating life with headaches.
Medical Disclaimer
The information and advice provided on this site do not replace the advice, diagnosis, or treatment of a healthcare professional. Please note that the author of this article is neither a doctor nor a specialist in a medical specialty as defined by the Collège des médecins du Québec. Manual medicine, functional medicine, and sports medicine as described on this site exclude any medical treatment or diagnosis made by a doctor or medical specialist. Always consult your doctor for any medical questions. For more details, please read our complete Legal Notice.
References
- Choi, S.-Y., & Choi, J.-H. (2016). The effects of cervical traction, cranial rhythmic impulse, and Mckenzie exercise on headache and cervical muscle stiffness in episodic tension-type headache patients. Journal of Physical Therapy Science, 28(3), 837–843. https://www.jstage.jst.go.jp/article/jpts/28/3/28_jpts-2015-893/_article/-char/ja/
- Fernández-de-las-Peñas, C., Madeleine, P., Caminero, A., Cuadrado, M., Arendt-Nielsen, L., & Pareja, J. (2010). Generalized Neck-Shoulder Hyperalgesia in Chronic Tension-Type Headache and Unilateral Migraine Assessed by Pressure Pain Sensitivity Topographical Maps of the Trapezius Muscle. Cephalalgia, 30(1), 77–86. https://doi.org/10.1111/j.1468-2982.2009.01901.x
- Al-Khazali, H. M., Younis, S., Al-Sayegh, Z., Ashina, S., Ashina, M., & Schytz, H. W. (2022). Prevalence of neck pain in migraine: A systematic review and meta-analysis. Cephalalgia, 42(7), 663–673. https://doi.org/10.1177/03331024211068073
- Zwart, J. (1997). Neck Mobility in Different Headache Disorders. Headache: The Journal of Head and Face Pain, 37(1), 6–11. https://doi.org/10.1046/j.1526-4610.1997.3701006.x
- Balaban, M., Celenay, S. T., Lalecan, N., Akan, S., & Kaya, D. O. (2024). Morphological and mechanical properties of cervical muscles in fibromyalgia with migraine: A case-control study. Musculoskeletal Science and Practice, 74, 103185. https://www.sciencedirect.com/science/article/pii/S2468781224002807
- Martínez-Merinero, P., Aneiros Tarancón, F., Montañez-Aguilera, J., Nuñez-Nagy, S., Pecos-Martín, D., Fernández-Matías, R., Achalandabaso-Ochoa, A., Fernández-Carnero, S., & Gallego-Izquierdo, T. (2021). Interaction between pain, disability, mechanosensitivity and cranio-cervical angle in subjects with cervicogenic headache: A cross-sectional study. Journal of Clinical Medicine, 10(1), 159. https://www.mdpi.com/2077-0383/10/1/159
- Calhoun, A. H., Ford, S., Millen, C., Finkel, A. G., Truong, Y., & Nie, Y. (2010). The Prevalence of Neck Pain in Migraine. Headache: The Journal of Head and Face Pain, 50(8), 1273–1277. https://doi.org/10.1111/j.1526-4610.2009.01608.x
- Hvedstrup, J., Kolding, L. T., Ashina, M., & Schytz, H. W. (2020). Increased neck muscle stiffness in migraine patients with ictal neck pain: A shear wave elastography study. Cephalalgia, 40(6), 565–574. https://doi.org/10.1177/0333102420919998
- Ashina, S., Bendtsen, L., Lyngberg, A. C., Lipton, R. B., Hajiyeva, N., & Jensen, R. (2015). Prevalence of neck pain in migraine and tension-type headache: A population study. Cephalalgia, 35(3), 211–219. https://doi.org/10.1177/0333102414535110
- Florencio, L. L., De Oliveira, A. S., Carvalho, G. F., Tolentino, G. D. A., Dach, F., Bigal, M. E., Fernández‐de‐las‐Peñas, C., & Bevilaqua Grossi, D. (2015). Cervical Muscle Strength and Muscle Coactivation During Isometric Contractions in Patients With Migraine: A Cross‐Sectional Study. Headache: The Journal of Head and Face Pain, 55(10), 1312–1322. https://doi.org/10.1111/head.12644
- Bjarne, B. (2024). NECK MUSCLE ELASTICITY IN CERVICOGENIC HEADACHE PATIENTS MEASURED BY SHEAR WAVE ELASTOGRAPHY [PhD Thesis, Ghent University]. https://libstore.ugent.be/fulltxt/RUG01/003/202/979/RUG01-003202979_2024_0001_AC.pdf
- Pradhan, S., & Choudhury, S. S. (2018). Clinical characterization of neck pain in migraine. Neurology India, 66(2), 377–384. https://journals.lww.com/neur/fulltext/2018/66020/clinical_characterization_of_neck_pain_in_migraine.19.aspx
- Al-Khazali, H. M., Al-Sayegh, Z., Younis, S., Christensen, R. H., Ashina, M., Schytz, H. W., & Ashina, S. (2024). Systematic review and meta-analysis of Neck Disability Index and Numeric Pain Rating Scale in patients with migraine and tension-type headache. Cephalalgia, 44(8), 03331024241274266. https://doi.org/10.1177/03331024241274266
- Lin, L.-Z., Yu, Y.-N., Fan, J.-C., Guo, P.-W., Xia, C.-F., Geng, X., Zhang, S.-Y., & Yuan, X.-Z. (2022). Increased stiffness of the superficial cervical extensor muscles in patients with cervicogenic headache: A study using shear wave elastography. Frontiers in Neurology, 13, 874643. https://www.frontiersin.org/articles/10.3389/fneur.2022.874643/full
- Fernández-de-las-Peñas, C., Cuadrado, M., & Pareja, J. (2006). Myofascial Trigger Points, Neck Mobility and Forward Head Posture in Unilateral Migraine. Cephalalgia, 26(9), 1061–1070. https://doi.org/10.1111/j.1468-2982.2006.01162.x
- Aoyama, N. (2021). Involvement of cervical disability in migraine: a literature review. British Journal of Pain, 15(2), 199–212. https://doi.org/10.1177/2049463720924704
- Fernández‐de‐las‐Peñas, C., Cuadrado, M. L., & Pareja, J. A. (2007). Myofascial Trigger Points, Neck Mobility, and Forward Head Posture in Episodic Tension‐Type Headache. Headache: The Journal of Head and Face Pain, 47(5), 662–672. https://doi.org/10.1111/j.1526-4610.2006.00632.x
- Luedtke, K., Starke, W., & May, A. (2018). Musculoskeletal dysfunction in migraine patients. Cephalalgia, 38(5), 865–875. https://doi.org/10.1177/0333102417716934
- Kolding, L. T., Do, T. P., Ewertsen, C., & Schytz, H. W. (2018). Muscle stiffness in tension-type headache patients with pericranial tenderness: A shear wave elastography study. Cephalalgia Reports, 1, 2515816318760293. https://doi.org/10.1177/2515816318760293
- Yu, Z., Wang, R., Ao, R., & Yu, S. (2019). Neck pain in episodic migraine: a cross-sectional study. Journal of Pain Research, Volume 12, 1605–1613. https://doi.org/10.2147/JPR.S200606
